Amyotrophic Lateral Sclerosis online Database - ALSoD

ALSOD aims to collate published ALS assoicated genes and variants, the database can be queried using the search bar or use the links below to start your search.

We are in the process of updating the website and database, as such not all features are live and not all ALS associated genes and variants are present. If there are features not available in this updated version.


All genes in ALSOD


Gene name Other names Protein name
AGT ANHU; FLJ92595; FLJ97926; SERPINA8; AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALAD "porphobilinogen synthase" d-Aminolevulinic Acid Dehydratase
ALS2 ALSJ; PLSJ; IAHSP; ALS2CR6; FLJ31851; KIAA1563; MGC87187 alsin
ALS3 amyotrophic lateral sclerosis 3 (autosomal dominant)
ALS7 amyotrophic lateral sclerosis 7
ANG RNASE5; ALS9 angiogenin, ribonuclease, RNase A family 5
APEX1 APE; APX; APE1; APEN; APEX; HAP1; REF1; APE-1; REF-1 APEX nuclease (multifunctional DNA repair enzyme) 1
APOE AD2; LPG; MGC1571; apoprotein apolipoprotein E
AR KD; AIS; TFM; DHTR; SBMA; NR3C4; SMAX1; HUMARA androgen receptor
ARHGEF28 RIP2; RGNEF; p190RHOGEF Rho guanine nucleotide exchange factor (GEF) 28
ATXN2 ATX2; SCA2; TNRC13; FLJ46772; ATXN2 ataxin 2
B4GALT6 B4Gal-T6; beta4Gal-T6; B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide
BCL11B RIT1; CTIP2; CTIP-2; ZNF856B; hRIT1-alpha B-cell CLL/lymphoma 11B (zinc finger protein)
BCL6 BCL5; LAZ3; BCL6A; ZNF51; ZBTB27 B-cell CLL/lymphoma 6
C1orf27 ODR4; TTG1; odr-4; FLJ20505; C1orf27 chromosome 1 open reading frame 27
C9orf72 MGC23980; RP11-27J8.2; C9orf72 chromosome 9 open reading frame 72
CCS MGC138260 copper chaperone for superoxide dismutase
CDH13 CDHH; P105 cadherin 13, H-cadherin (heart)
CDH22 C20orf25; MGC39564; dJ998H6.1 cadherin 22, type 2
CHCHD10 FTDALS2; N27C7-4; C22orf16 coiled-coil-helix-coiled-coil-helix domain containing 10
CHGB SCG1 chromogranin B (secretogranin 1)
CHMP2B DMT1; VPS2B; VPS2-2; CHMP2.5; DKFZp564O123; CHMP2B chromatin modifying protein 2B
CNTF HCNTF ciliary neurotrophic factor
CNTN4 AXCAM; BIG-2; CNTN4A; MGC33615; CNTN4 contactin 4
CNTN6 NB3; MGC133256 DOC2B double C2-like domains, beta
CRIM1 S52; CRIM-1; MGC138194 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CRYM THBP; DFNA40; CRYM crystallin, mu
CSNK1G3 CSNK1G3 casein kinase 1, gamma 3
CST3 ARMD11; MGC117328 cystatin C
CX3CR1 V28; CCRL1; GPR13; CMKDR1; GPRV28; CMKBRL1 chemokine (C-X3-C motif) receptor 1
CYP2D6 "cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6",CPD6, P450-DB1, CYP2D, P450C2D cytochrome P450, family 2, subfamily D, polypeptide 6
DAO DAAO; OXDA; DAMOX; MGC35381; DAO D-amino-acid oxidase
DCTN1 P135; HMN7B; DP-150; DAP-150 dynactin 1 (p150, glued homolog, Drosophila)
DIAPH3 AN; DRF3; AUNA1; NSDAN; diap3; mDia2; FLJ34705; DKFZp434C0931; DKFZp686A13178 diaphanous homolog 3 (Drosophila)
DISC1 SCZD9; C1orf136; FLJ13381; FLJ21640; FLJ25311; FLJ41105; KIAA0457; DISC1 disrupted in schizophrenia 1
DOC2B DOC2BL double C2-like domains, beta
DPP6 VF2; DPPX; FLJ55680; MGC46605; DPP6 dipeptidyl-peptidase 6
DYNC1H1 p22; DHC1; DNCL; DYHC; HL-3; DHC1a; DNCH1; DNECL; Dnchc1; KIAA0325; DKFZp686P2245 dynein, cytoplasmic 1, heavy chain 1
EFEMP1 DHRD; DRAD; FBNL; MLVT; MTLV; S1-5; FBLN3; FLJ35535; MGC111353; EFEMP1 EGF-containing fibulin-like extracellular matrix protein 1
ELP3 FLJ10422, KAT9 elongation protein 3 homolog (S. cerevisiae)
EPHA4 SEK; HEK8; TYRO1 EPH receptor A4
ERBB4 ALS19 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
EWSR1 EWS; bK984G1.4 Ewing sarcoma breakpoint region 1
FEZF2 FEZ; TOF; FEZL; FKSG36; ZFP312; ZNF312; FLJ10142 FEZ family zinc finger 2
FGGY FLJ10986; RP11-242B9.1; FGGY FLJ10986
FIG4 SAC3; ALS11; CMT4J; hSac3; KIAA0274; dJ249I4.1; RP1-249I4.1; FIG4 SAC domain-containing protein gene family
FUS TLS; CHOP; FUS1; FUS-CHOP; TLS/CHOP; hnRNP-P2; FUS; ALS6 FUS RNA binding protein
GARS HMN5; CMT2D; DSMAV; GlyRS; SMAD1 glycyl-tRNA synthetase
GLE1 LCCS; GLE1L; LCCS1; hGLE1 GLE1 RNA export mediator
GRB14 growth factor receptor-bound protein 14
GRN GEP; GP88; PEPI; PGRN; PCDGF; GRN progranulin
HEXA TSD; MGC99608 hexosaminidase A (alpha polypeptide)
HFE HH; HFE1; HLA-H; MGC103790; dJ221C16.10.1 hemochromatosis
HNRNPA1 hnRNPA1, hnRNP A1, hnRNP-A1, hnRNP core protein A1, HNRPA1, HNRPA1L3, MGC102835, Single-strand RNA-binding protein heterogeneous nuclear ribonucleoprotein A1
HNRNPA2B1 DKFZp779B0244, FLJ22720, Heterogeneous nuclear ribonucleoproteins A2/B1, HNRNPA2, hnRNP A2/B1, HNRNPB1, HNRPA2, HNRPA2B1, HNRPB1, RNPA2, SNRPB1 heterogeneous nuclear ribonucleoprotein A2/B1
ITPR2 IP3R2; ITPR2
KDR FLK1; CD309; VEGFR; VEGFR2; KDR kinase insert domain receptor (a type III receptor tyrosine kinase)
KIFAP3 KAP3; SMAP; Smg-GDS; FLJ22818; dJ190I16.1; KIFAP3 kinesin-associated protein 3
LIF CDF; HILDA; D-FACTOR leukemia inhibitory factor (cholinergic differentiation factor)
LIPC HL; HTGL; LIPH; HDLCQ12; LIPC lipase, hepatic
LMNB1 - lamin B1
LOX MGC105112 lysyl oxidase
LUM LDC; SLRR2D; LUM lumican
MAOB MGC26382 monoamine oxidase B
MAPT TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; FLJ31424; MGC138549 microtubule-associated protein tau
MATR3 MPD2; ALS21; VCPDM matrin 3
MT-ND2 MTND2 mitochondrially encoded NADH dehydrogenase 2
NAIP BIRC1; NLRB1; psiNAIP; FLJ42520 NLR family, apoptosis inhibitory protein
NEFH NFH Neurofilament heavy polypeptide (NF-H)
NETO1 BCTL1; BTCL1; FLJ41325 neuropilin (NRP) and tolloid (TLL)-like 1
NIPA1 FSP3; SPG6; MGC35570 non imprinted in Prader-Willi/Angelman syndrome 1
NT5C1A CN1; CN-I; CN1A; CN-IA; MGC119199; MGC119201; NT5C1A 5'-nucleotidase, cytosolic IA
OGG1 HMMH; MUTM; OGH1; HOGG1; OGG1 8-oxoguanine DNA glycosylase
OMA1 DAB1; MPRP-1; YKR087C; ZMPOMA1; FLJ33782; 2010001O09Rik OMA1 homolog, zinc metallopeptidase (S. cerevisiae)
OPTN NRP; FIP2; HIP7; HYPL; GLC1E; TFIIIA-INTP; OPTN optineurin
PARK7 DJ-1, DJ1 parkinson protein 7
PCP4 PEP-19 Purkinje cell protein 4
PFN1 ALS18 profilin 1
PLEKHG5 - pleckstrin homology domain containing, family G (with RhoGef domain) member 5
PON1 ESA; PON paraoxonase 1
PON2 "paraoxonase nirs" paraoxonase 2
PON3 paraoxonase 3
PRPH NEF4; PRPH1 peripherin
PSEN1 AD3; FAD; PS1; S182; "Alzheimer disease 3" presenilin 1
PVR PVS; HVED; CD155; NECL5; TAGE4; Necl-5 Poliovirus receptor
RAMP3 receptor (G protein-coupled) activity modifying protein 3
RBMS1 YC1; MSSP; SCR2; HCC-4; MSSP-1; MSSP-2; MSSP-3; C2orf12; MGC3331; MGC15146; MGC70597; MGC97258; MGC97270; MGC97282; MGC99543; DKFZp564H0764; RBMS1 RNA binding motif, single stranded interacting protein 1
RNASE2 EDN; RNS2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RNF19A RNF19; DORFIN; DKFZp566B1346; RNF19A ring finger protein 19A
SARM1 KIAA0524, SAMD2, SARM; MyD88-5 sterile alpha and TIR motif containing 1
SCN7A SCN6A; SCN7A sodium channel, voltage-gated, type VII, alpha
SELL TQ1; LAM1; LEU8; LNHR; LSEL; CD62L; LYAM1; PLNHR; LECAM1; SELL selectin L
SEMA6A VIA; SEMA; HT018; SEMAQ; SEMA6A1; KIAA1368; SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SETX ALS4; AOA2; SCAR1; FLJ12840; FLJ43459; KIAA0625; bA479K20.2; DKFZp781B151 senataxin
SIGMAR1 SRBP; OPRS1; SR-BP1 Sigma non-opioid intracellular receptor 1
SLC1A2 EAAT2; GLT-1 solute carrier family 1 (glial high affinity glutamate transporter), member 2
SLC39A11 ZIP11; C17orf26; SLC39A11 solute carrier family 39 (metal ion transporter), member 11
SMN1 SMA; SMN; SMA1; SMA2; SMA3; SMA4; SMA@; SMNT; BCD541; T-BCD541 survival of motor neuron 1, telomeric
SMN2 SMNC; BCD541; MGC5208; C-BCD541; FLJ76644; MGC20996 survival of motor neuron 2, centromeric
SNCG SR; BCSG1 synuclein, gamma (breast cancer-specific protein 1)
SOD1 ALS, ALS1 superoxide dismutase 1, soluble
SOD2 IPO-B; MNSOD; Mn-SOD superoxide dismutase 2, mitochondrial
SOX5 L-SOX5; MGC35153 SRY (sex determining region Y)-box 5
SPAST FSP2; SPG4; ADPSP; KIAA1083 spastin
SPG11 FLJ21439; KIAA1840; DKFZp762B1512 Spatacsin
SPG7 CAR; PGN; CMAR; SPG5C; FLJ37308; MGC126331; MGC126332 spastic paraplegia 7 (pure and complicated autosomal recessive)
SQSTM1 p60; p62; A170; OSIL; PDB3; ZIP3; p62B sequestosome 1
SS18L1 CREST; LP2261; KIAA0693 synovial sarcoma translocation gene on chromosome 18-like 1
SUSD1 RP11-4O1.1; SUSD1; DKFZP761E1824 sushi domain containing 1
SYNE spectrin repeat containing, nuclear envelope 1
SYT9 FLJ45896 synaptotagmin IX
TAF15 Npl3; RBP56; TAF2N; TAFII68; hTAFII68 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TARDBP ALS10; TDP-43 TAR DNA binding protein
TBK1 NAK; T2K TANK-binding kinase 1
TRPM7 CHAK; CHAK1; ALSPDC; LTRPC7; LTrpC-7; TRP-PLIK transient receptor potential cation channel, subfamily M, member 7
TUBA4A TUBA1; H2-ALPHA tubulin, alpha 4a
UBQLN2 DSK2; CHAP1; N4BP4; PLIC2; FLJ10167; FLJ56541; HRIHFB2157 ubiquilin 2
UNC13A KIAA1032; Munc13-1; UNC13A protein unc-13 homolog A
VAPB ALS8; VAP-B; VAP-C; VAMP-B; VAMP-C: VAMP (vesicle-associated membrane protein)-associated protein B and C
VCP p97; TERA; IBMPFD; MGC8560; MGC131997; MGC148092; VCP valosin-containing protein
VDR NR1I1 vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA VPF; VEGF; VEGF-A; MGC70609 vascular endothelial growth factor A
VPS54 HCC8; SLP-8p; VPS54L; hVps54L; VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae)
ZFP64 FLJ10734, dJ831D17.1, FLJ12628, dJ548G19.1; MGC940; ZNF338; ZFP64 zinc finger protein 64 homolog
ZNF512B GM632, MGC149845, MGC149846 zinc finger protein 512B
ZNF746 FLJ31413; ZNF746 zinc finger protein 746