Amyotrophic Lateral Sclerosis online Database - ALSoD
ALSOD aims to collate published ALS assoicated genes and variants, the database can be queried using the search bar or use the links below to start your search.
We are in the process of updating the website and database, as such not all features are live and not all ALS associated genes and variants are present. If there are features not available in this updated version.
All genes in ALSOD
| Gene name | Other names | Protein name | |
|---|---|---|---|
| AGT | ANHU; FLJ92595; FLJ97926; SERPINA8; AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | |
| ALAD | "porphobilinogen synthase" | d-Aminolevulinic Acid Dehydratase | |
| ALS2 | ALSJ; PLSJ; IAHSP; ALS2CR6; FLJ31851; KIAA1563; MGC87187 | alsin | |
| ALS3 | amyotrophic lateral sclerosis 3 (autosomal dominant) | ||
| ALS7 | amyotrophic lateral sclerosis 7 | ||
| ANG | RNASE5; ALS9 | angiogenin, ribonuclease, RNase A family 5 | |
| APEX1 | APE; APX; APE1; APEN; APEX; HAP1; REF1; APE-1; REF-1 | APEX nuclease (multifunctional DNA repair enzyme) 1 | |
| APOE | AD2; LPG; MGC1571; apoprotein | apolipoprotein E | |
| AR | KD; AIS; TFM; DHTR; SBMA; NR3C4; SMAX1; HUMARA | androgen receptor | |
| ARHGEF28 | RIP2; RGNEF; p190RHOGEF | Rho guanine nucleotide exchange factor (GEF) 28 | |
| ATXN2 | ATX2; SCA2; TNRC13; FLJ46772; ATXN2 | ataxin 2 | |
| B4GALT6 | B4Gal-T6; beta4Gal-T6; B4GALT6 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide | |
| BCL11B | RIT1; CTIP2; CTIP-2; ZNF856B; hRIT1-alpha | B-cell CLL/lymphoma 11B (zinc finger protein) | |
| BCL6 | BCL5; LAZ3; BCL6A; ZNF51; ZBTB27 | B-cell CLL/lymphoma 6 | |
| C1orf27 | ODR4; TTG1; odr-4; FLJ20505; C1orf27 | chromosome 1 open reading frame 27 | |
| C9orf72 | MGC23980; RP11-27J8.2; C9orf72 | chromosome 9 open reading frame 72 | |
| CCS | MGC138260 | copper chaperone for superoxide dismutase | |
| CDH13 | CDHH; P105 | cadherin 13, H-cadherin (heart) | |
| CDH22 | C20orf25; MGC39564; dJ998H6.1 | cadherin 22, type 2 | |
| CHCHD10 | FTDALS2; N27C7-4; C22orf16 | coiled-coil-helix-coiled-coil-helix domain containing 10 | |
| CHGB | SCG1 | chromogranin B (secretogranin 1) | |
| CHMP2B | DMT1; VPS2B; VPS2-2; CHMP2.5; DKFZp564O123; CHMP2B | chromatin modifying protein 2B | |
| CNTF | HCNTF | ciliary neurotrophic factor | |
| CNTN4 | AXCAM; BIG-2; CNTN4A; MGC33615; CNTN4 | contactin 4 | |
| CNTN6 | NB3; MGC133256 | DOC2B double C2-like domains, beta | |
| CRIM1 | S52; CRIM-1; MGC138194 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | |
| CRYM | THBP; DFNA40; CRYM | crystallin, mu | |
| CSNK1G3 | CSNK1G3 | casein kinase 1, gamma 3 | |
| CST3 | ARMD11; MGC117328 | cystatin C | |
| CX3CR1 | V28; CCRL1; GPR13; CMKDR1; GPRV28; CMKBRL1 | chemokine (C-X3-C motif) receptor 1 | |
| CYP2D6 | "cytochrome P450, subfamily IID (debrisoquine, sparteine, etc., -metabolizing), polypeptide 6",CPD6, P450-DB1, CYP2D, P450C2D | cytochrome P450, family 2, subfamily D, polypeptide 6 | |
| DAO | DAAO; OXDA; DAMOX; MGC35381; DAO | D-amino-acid oxidase | |
| DCTN1 | P135; HMN7B; DP-150; DAP-150 | dynactin 1 (p150, glued homolog, Drosophila) | |
| DIAPH3 | AN; DRF3; AUNA1; NSDAN; diap3; mDia2; FLJ34705; DKFZp434C0931; DKFZp686A13178 | diaphanous homolog 3 (Drosophila) | |
| DISC1 | SCZD9; C1orf136; FLJ13381; FLJ21640; FLJ25311; FLJ41105; KIAA0457; DISC1 | disrupted in schizophrenia 1 | |
| DOC2B | DOC2BL | double C2-like domains, beta | |
| DPP6 | VF2; DPPX; FLJ55680; MGC46605; DPP6 | dipeptidyl-peptidase 6 | |
| DYNC1H1 | p22; DHC1; DNCL; DYHC; HL-3; DHC1a; DNCH1; DNECL; Dnchc1; KIAA0325; DKFZp686P2245 | dynein, cytoplasmic 1, heavy chain 1 | |
| EFEMP1 | DHRD; DRAD; FBNL; MLVT; MTLV; S1-5; FBLN3; FLJ35535; MGC111353; EFEMP1 | EGF-containing fibulin-like extracellular matrix protein 1 | |
| ELP3 | FLJ10422, KAT9 | elongation protein 3 homolog (S. cerevisiae) | |
| EPHA4 | SEK; HEK8; TYRO1 | EPH receptor A4 | |
| ERBB4 | ALS19 | v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 | |
| EWSR1 | EWS; bK984G1.4 | Ewing sarcoma breakpoint region 1 | |
| FEZF2 | FEZ; TOF; FEZL; FKSG36; ZFP312; ZNF312; FLJ10142 | FEZ family zinc finger 2 | |
| FGGY | FLJ10986; RP11-242B9.1; FGGY | FLJ10986 | |
| FIG4 | SAC3; ALS11; CMT4J; hSac3; KIAA0274; dJ249I4.1; RP1-249I4.1; FIG4 | SAC domain-containing protein gene family | |
| FUS | TLS; CHOP; FUS1; FUS-CHOP; TLS/CHOP; hnRNP-P2; FUS; ALS6 | FUS RNA binding protein | |
| GARS | HMN5; CMT2D; DSMAV; GlyRS; SMAD1 | glycyl-tRNA synthetase | |
| GLE1 | LCCS; GLE1L; LCCS1; hGLE1 | GLE1 RNA export mediator | |
| GRB14 | growth factor receptor-bound protein 14 | ||
| GRN | GEP; GP88; PEPI; PGRN; PCDGF; GRN | progranulin | |
| HEXA | TSD; MGC99608 | hexosaminidase A (alpha polypeptide) | |
| HFE | HH; HFE1; HLA-H; MGC103790; dJ221C16.10.1 | hemochromatosis | |
| HNRNPA1 | hnRNPA1, hnRNP A1, hnRNP-A1, hnRNP core protein A1, HNRPA1, HNRPA1L3, MGC102835, Single-strand RNA-binding protein | heterogeneous nuclear ribonucleoprotein A1 | |
| HNRNPA2B1 | DKFZp779B0244, FLJ22720, Heterogeneous nuclear ribonucleoproteins A2/B1, HNRNPA2, hnRNP A2/B1, HNRNPB1, HNRPA2, HNRPA2B1, HNRPB1, RNPA2, SNRPB1 | heterogeneous nuclear ribonucleoprotein A2/B1 | |
| ITPR2 | IP3R2; ITPR2 | ||
| KDR | FLK1; CD309; VEGFR; VEGFR2; KDR | kinase insert domain receptor (a type III receptor tyrosine kinase) | |
| KIFAP3 | KAP3; SMAP; Smg-GDS; FLJ22818; dJ190I16.1; KIFAP3 | kinesin-associated protein 3 | |
| LIF | CDF; HILDA; D-FACTOR | leukemia inhibitory factor (cholinergic differentiation factor) | |
| LIPC | HL; HTGL; LIPH; HDLCQ12; LIPC | lipase, hepatic | |
| LMNB1 | - | lamin B1 | |
| LOX | MGC105112 | lysyl oxidase | |
| LUM | LDC; SLRR2D; LUM | lumican | |
| MAOB | MGC26382 | monoamine oxidase B | |
| MAPT | TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; FLJ31424; MGC138549 | microtubule-associated protein tau | |
| MATR3 | MPD2; ALS21; VCPDM | matrin 3 | |
| MT-ND2 | MTND2 | mitochondrially encoded NADH dehydrogenase 2 | |
| NAIP | BIRC1; NLRB1; psiNAIP; FLJ42520 | NLR family, apoptosis inhibitory protein | |
| NEFH | NFH | Neurofilament heavy polypeptide (NF-H) | |
| NETO1 | BCTL1; BTCL1; FLJ41325 | neuropilin (NRP) and tolloid (TLL)-like 1 | |
| NIPA1 | FSP3; SPG6; MGC35570 | non imprinted in Prader-Willi/Angelman syndrome 1 | |
| NT5C1A | CN1; CN-I; CN1A; CN-IA; MGC119199; MGC119201; NT5C1A | 5'-nucleotidase, cytosolic IA | |
| OGG1 | HMMH; MUTM; OGH1; HOGG1; OGG1 | 8-oxoguanine DNA glycosylase | |
| OMA1 | DAB1; MPRP-1; YKR087C; ZMPOMA1; FLJ33782; 2010001O09Rik | OMA1 homolog, zinc metallopeptidase (S. cerevisiae) | |
| OPTN | NRP; FIP2; HIP7; HYPL; GLC1E; TFIIIA-INTP; OPTN | optineurin | |
| PARK7 | DJ-1, DJ1 | parkinson protein 7 | |
| PCP4 | PEP-19 | Purkinje cell protein 4 | |
| PFN1 | ALS18 | profilin 1 | |
| PLEKHG5 | - | pleckstrin homology domain containing, family G (with RhoGef domain) member 5 | |
| PON1 | ESA; PON | paraoxonase 1 | |
| PON2 | "paraoxonase nirs" | paraoxonase 2 | |
| PON3 | paraoxonase 3 | ||
| PRPH | NEF4; PRPH1 | peripherin | |
| PSEN1 | AD3; FAD; PS1; S182; "Alzheimer disease 3" | presenilin 1 | |
| PVR | PVS; HVED; CD155; NECL5; TAGE4; Necl-5 | Poliovirus receptor | |
| RAMP3 | receptor (G protein-coupled) activity modifying protein 3 | ||
| RBMS1 | YC1; MSSP; SCR2; HCC-4; MSSP-1; MSSP-2; MSSP-3; C2orf12; MGC3331; MGC15146; MGC70597; MGC97258; MGC97270; MGC97282; MGC99543; DKFZp564H0764; RBMS1 | RNA binding motif, single stranded interacting protein 1 | |
| RNASE2 | EDN; RNS2 | ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin) | |
| RNF19A | RNF19; DORFIN; DKFZp566B1346; RNF19A | ring finger protein 19A | |
| SARM1 | KIAA0524, SAMD2, SARM; MyD88-5 | sterile alpha and TIR motif containing 1 | |
| SCN7A | SCN6A; SCN7A | sodium channel, voltage-gated, type VII, alpha | |
| SELL | TQ1; LAM1; LEU8; LNHR; LSEL; CD62L; LYAM1; PLNHR; LECAM1; SELL | selectin L | |
| SEMA6A | VIA; SEMA; HT018; SEMAQ; SEMA6A1; KIAA1368; SEMA6A | sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A | |
| SETX | ALS4; AOA2; SCAR1; FLJ12840; FLJ43459; KIAA0625; bA479K20.2; DKFZp781B151 | senataxin | |
| SIGMAR1 | SRBP; OPRS1; SR-BP1 | Sigma non-opioid intracellular receptor 1 | |
| SLC1A2 | EAAT2; GLT-1 | solute carrier family 1 (glial high affinity glutamate transporter), member 2 | |
| SLC39A11 | ZIP11; C17orf26; SLC39A11 | solute carrier family 39 (metal ion transporter), member 11 | |
| SMN1 | SMA; SMN; SMA1; SMA2; SMA3; SMA4; SMA@; SMNT; BCD541; T-BCD541 | survival of motor neuron 1, telomeric | |
| SMN2 | SMNC; BCD541; MGC5208; C-BCD541; FLJ76644; MGC20996 | survival of motor neuron 2, centromeric | |
| SNCG | SR; BCSG1 | synuclein, gamma (breast cancer-specific protein 1) | |
| SOD1 | ALS, ALS1 | superoxide dismutase 1, soluble | |
| SOD2 | IPO-B; MNSOD; Mn-SOD | superoxide dismutase 2, mitochondrial | |
| SOX5 | L-SOX5; MGC35153 | SRY (sex determining region Y)-box 5 | |
| SPAST | FSP2; SPG4; ADPSP; KIAA1083 | spastin | |
| SPG11 | FLJ21439; KIAA1840; DKFZp762B1512 | Spatacsin | |
| SPG7 | CAR; PGN; CMAR; SPG5C; FLJ37308; MGC126331; MGC126332 | spastic paraplegia 7 (pure and complicated autosomal recessive) | |
| SQSTM1 | p60; p62; A170; OSIL; PDB3; ZIP3; p62B | sequestosome 1 | |
| SS18L1 | CREST; LP2261; KIAA0693 | synovial sarcoma translocation gene on chromosome 18-like 1 | |
| SUSD1 | RP11-4O1.1; SUSD1; DKFZP761E1824 | sushi domain containing 1 | |
| SYNE | spectrin repeat containing, nuclear envelope 1 | ||
| SYT9 | FLJ45896 | synaptotagmin IX | |
| TAF15 | Npl3; RBP56; TAF2N; TAFII68; hTAFII68 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | |
| TARDBP | ALS10; TDP-43 | TAR DNA binding protein | |
| TBK1 | NAK; T2K | TANK-binding kinase 1 | |
| TRPM7 | CHAK; CHAK1; ALSPDC; LTRPC7; LTrpC-7; TRP-PLIK | transient receptor potential cation channel, subfamily M, member 7 | |
| TUBA4A | TUBA1; H2-ALPHA | tubulin, alpha 4a | |
| UBQLN2 | DSK2; CHAP1; N4BP4; PLIC2; FLJ10167; FLJ56541; HRIHFB2157 | ubiquilin 2 | |
| UNC13A | KIAA1032; Munc13-1; UNC13A | protein unc-13 homolog A | |
| VAPB | ALS8; VAP-B; VAP-C; VAMP-B; VAMP-C: | VAMP (vesicle-associated membrane protein)-associated protein B and C | |
| VCP | p97; TERA; IBMPFD; MGC8560; MGC131997; MGC148092; VCP | valosin-containing protein | |
| VDR | NR1I1 | vitamin D (1,25- dihydroxyvitamin D3) receptor | |
| VEGFA | VPF; VEGF; VEGF-A; MGC70609 | vascular endothelial growth factor A | |
| VPS54 | HCC8; SLP-8p; VPS54L; hVps54L; VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | |
| ZFP64 | FLJ10734, dJ831D17.1, FLJ12628, dJ548G19.1; MGC940; ZNF338; ZFP64 | zinc finger protein 64 homolog | |
| ZNF512B | GM632, MGC149845, MGC149846 | zinc finger protein 512B | |
| ZNF746 | FLJ31413; ZNF746 | zinc finger protein 746 |