|
AGT |
angiotensinogen |
Tenuous |
|
ALAD |
aminolevulinate dehydratase |
Tenuous |
|
ALS2 |
alsin Rho guanine nucleotide exchange factor ALS2 |
Tenuous |
|
ALS3 |
amyotrophic lateral sclerosis 3 (autosomal dominant) |
Tenuous |
|
ALS7 |
amyotrophic lateral sclerosis 7 |
Tenuous |
|
ANG |
angiogenin |
Moderate evidence |
|
ANXA11 |
annexin A11 |
Definitive ALS gene |
|
APEX1 |
apurinic/apyrimidinic endodeoxyribonuclease 1 |
Tenuous |
|
APOE |
apolipoprotein E |
Tenuous |
|
AR |
androgen receptor |
Tenuous |
|
ARHGEF28 |
rho guanine nucleotide exchange factor 28 |
Moderate evidence |
|
ARPP21 |
cAMP Regulated Phosphoprotein 21 |
Tenuous |
|
ATXN1 |
ataxin 1 |
Strong evidence |
|
ATXN2 |
ataxin 2 |
Clinical modifier |
|
B4GALT6 |
beta-1,4-galactosyltransferase 6 |
Tenuous |
|
BCL11B |
BAF chromatin remodeling complex subunit BCL11B |
Tenuous |
|
BCL6 |
BCL6 transcription repressor |
Tenuous |
|
C9orf72 |
C9orf72-SMCR8 complex subunit |
Definitive ALS gene |
|
CAMTA1 |
Calmodulin brinding transcriptions activator 1 |
Clinical modifier |
|
CAV1 |
caveolin 1 |
Unassigned |
|
CAV2 |
caveolin 2 |
Unassigned |
|
CCNF |
cyclin F |
Strong evidence |
|
CCS |
copper chaperone for superoxide dismutase |
Tenuous |
|
CDH13 |
cadherin 13 |
Tenuous |
|
CDH22 |
cadherin 22 |
Moderate evidence |
|
CFAP410 |
Cilia and Flagella Associated Protein 410 |
Strong evidence |
|
CHCHD10 |
coiled-coil-helix-coiled-coil-helix domain containing 10 |
Definitive ALS gene |
|
CHGB |
chromogranin B |
Tenuous |
|
CHMP2B |
charged multivesicular body protein 2B |
Moderate evidence |
|
CNTF |
ciliary neurotrophic factor |
Tenuous |
|
CNTN4 |
contactin 4 |
Tenuous |
|
CNTN6 |
contactin 6 |
Moderate evidence |
|
CRIM1 |
cysteine rich transmembrane BMP regulator 1 |
Tenuous |
|
CRYM |
crystallin mu |
Moderate evidence |
|
CSNK1G3 |
casein kinase 1 gamma 3 |
Moderate evidence |
|
CST3 |
cystatin C |
Tenuous |
|
CX3CR1 |
C-X3-C motif chemokine receptor 1 |
Moderate evidence |
|
CYP2D6 |
Cytochrome P450 family 2 subfamily D member 6 |
Tenuous |
|
DAO |
D-amino acid oxidase |
Moderate evidence |
|
DCTN1 |
dynactin subunit 1 |
Tenuous |
|
DIAPH3 |
diaphanous related formin 3 |
Tenuous |
|
DISC1 |
DISC1 scaffold protein |
Tenuous |
|
DNAJC7 |
DnaJ heat shock protein family (Hsp40) member C7 |
Moderate evidence |
|
DNMT3A |
DNA methyltransferase 3 alpha |
Moderate evidence |
|
DNMT3B |
DNA methyltransferase 3 beta |
Tenuous |
|
DOC2B |
double C2 domain beta |
Tenuous |
|
DPP6 |
dipeptidyl peptidase like 6 |
Tenuous |
|
DYNC1H1 |
dynein cytoplasmic 1 heavy chain 1 |
Tenuous |
|
EFEMP1 |
EGF containing fibulin extracellular matrix protein 1 |
Tenuous |
|
ELP3 |
elongator acetyltransferase complex subunit 3 |
Tenuous |
|
ENAH |
ENAH actin regulator |
Clinical modifier |
|
EphA3 |
EPH receptor A3 |
Tenuous |
|
EPHA4 |
EPH receptor A4 |
Definitive ALS gene |
|
ERBB4 |
erb-b2 receptor tyrosine kinase 4 |
Moderate evidence |
|
ERLIN1 |
ER lipid raft associated 1 |
Tenuous |
|
EWSR1 |
EWS RNA binding protein 1 |
Tenuous |
|
FEZF2 |
FEZ family zinc finger 2 |
Tenuous |
|
FGGY |
FGGY carbohydrate kinase domain containing |
Tenuous |
|
FIG4 |
FIG4 phosphoinositide 5-phosphatase |
Moderate evidence |
|
FUS |
FUS RNA binding protein |
Definitive ALS gene |
|
GARS |
glycyl-tRNA synthetase 1 |
Tenuous |
|
GLE1 |
GLE1 RNA export mediator |
Moderate evidence |
|
GLT8D1 |
glycosyltransferase 8 domain containing 1 |
Tenuous |
|
GPX3 |
glutathione peroxidase 3 |
Moderate evidence |
|
GRB14 |
growth factor receptor bound protein 14 |
Tenuous |
|
GRN |
granulin precursor |
Tenuous |
|
HEXA |
hexosaminidase subunit alpha |
Tenuous |
|
HFE |
homeostatic iron regulator |
Strong evidence |
|
HNRNPA1 |
heterogeneous nuclear ribonucleoprotein A1 |
Definitive ALS gene |
|
HNRNPA2B1 |
heterogeneous nuclear ribonucleoprotein A2/B1 |
Tenuous |
|
ITPR2 |
inositol 1,4,5-triphosphate receptor type 2 |
Tenuous |
|
KDR |
kinase insert domain receptor |
Tenuous |
|
KIF5A |
kinesin family member 5A |
Definitive ALS gene |
|
KIFAP3 |
kinesin associated protein 3 |
Tenuous |
|
LIF |
LIF interleukin 6 family cytokine |
Tenuous |
|
LIPC |
lipase C, hepatic type |
Tenuous |
|
LMNB1 |
lamin B1 |
Moderate evidence |
|
LOX |
lysyl oxidase |
Tenuous |
|
LUM |
lumican |
Tenuous |
|
MAOB |
monoamine oxidase B |
Tenuous |
|
MAPT |
microtubule associated protein tau |
Tenuous |
|
MATR3 |
matrin 3 |
Tenuous |
|
MOBP |
myelin associated oligodendrocyte basic protein |
Tenuous |
|
MTND2P1 |
MT-ND2 pseudogene 1 |
Tenuous |
|
NAIP |
NLR family apoptosis inhibitory protein |
Tenuous |
|
NEFH |
neurofilament heavy |
Tenuous |
|
NEFL |
neurofilament light |
Tenuous |
|
NEK1 |
NIMA related kinase 1 |
Definitive ALS gene |
|
NETO1 |
neuropilin and tolloid like 1 |
Tenuous |
|
NIPA1 |
NIPA magnesium transporter 1 |
Strong evidence |
|
NT5C1A |
5'-nucleotidase, cytosolic IA |
Tenuous |
|
ODR4 |
odr-4 GPCR localization factor homolog |
Tenuous |
|
OGG1 |
8-oxoguanine DNA glycosylase |
Tenuous |
|
OMA1 |
OMA1 zinc metallopeptidase |
Tenuous |
|
OPTN |
optineurin |
Definitive ALS gene |
|
PARK7 |
Parkinsonism associated deglycase |
Tenuous |
|
PCP4 |
Purkinje cell protein 4 |
Tenuous |
|
PFN1 |
profilin 1 |
Definitive ALS gene |
|
PLEKHG5 |
pleckstrin homology and RhoGEF domain containing G5 |
Tenuous |
|
PNPLA6 |
patatin like phospholipase domain containing 6 |
Tenuous |
|
PON1 |
paraoxonase 1 |
Tenuous |
|
PON2 |
paraoxonase 2 |
Tenuous |
|
PON3 |
paraoxonase 3 |
Tenuous |
|
PRPH |
peripherin |
Tenuous |
|
PSEN1 |
presenilin-1 |
Tenuous |
|
PVR |
PVR cell adhesion molecule |
Tenuous |
|
RAMP3 |
receptor activity modifying protein 3 |
Tenuous |
|
RBMS1 |
RNA binding motif single stranded interacting protein 1 |
Tenuous |
|
RFTN1 |
raftlin, lipid raft linker 1 |
Tenuous |
|
RNASE2 |
ribonuclease A family member 2 |
Tenuous |
|
RNF19A |
ring finger protein 19A, RBR E3 ubiquitin protein ligase |
Tenuous |
|
SARM1 |
sterile alpha and TIR motif containing 1 |
Moderate evidence |
|
SCFD1 |
sec1 family domain containing 1 |
Strong evidence |
|
SCN7A |
sodium voltage-gated channel alpha subunit 7 |
Tenuous |
|
SELL |
selectin L |
Tenuous |
|
SEMA6A |
semaphorin 6A |
Tenuous |
|
SETX |
senataxin |
Tenuous |
|
SIGMAR1 |
sigma non-opioid intracellular receptor 1 |
Tenuous |
|
SLC1A2 |
solute carrier family 1 member 2 |
Tenuous |
|
SLC39A11 |
solute carrier family 39 member 11 |
Tenuous |
|
SLC52A3 |
solute carrier family 52 member 3 |
Tenuous |
|
SMN1 |
survival of motor neuron 1, telomeric |
Moderate evidence |
|
SMN2 |
survival of motor neuron 2, centromeric |
Tenuous |
|
SNCG |
synuclein |
Tenuous |
|
SOD1 |
superoxide dismutase 1 |
Definitive ALS gene |
|
SOD2 |
superoxide dismutase 2 |
Tenuous |
|
SOX5 |
SRY-box transcription factor 5 |
Tenuous |
|
SPAST |
spastin |
Tenuous |
|
SPG11 |
SPG11 vesicle trafficking associated, spatacsin |
Tenuous |
|
SPG7 |
SPG7 matrix AAA peptidase subunit, paraplegin |
Tenuous |
|
SQSTM1 |
sequestosome 1 |
Moderate evidence |
|
SS18L1 |
SS18L1 subunit of BAF chromatin remodeling complex |
Moderate evidence |
|
SUSD1 |
sushi domain containing 1 |
Tenuous |
|
SYNE1 |
spectrin repeat containing nuclear envelope protein 1 |
Tenuous |
|
SYT9 |
synaptotagmin 9 |
Tenuous |
|
TAF15 |
TATA-box binding protein associated factor 15 |
Tenuous |
|
TARDBP |
TAR DNA binding protein |
Definitive ALS gene |
|
TBK1 |
TANK binding kinase 1 |
Definitive ALS gene |
|
TIA1 |
TIA1 cytotoxic granule associated RNA binding protein |
Tenuous |
|
TNIP1 |
TNFAIP3 interacting protein 1 |
Moderate evidence |
|
TRPM7 |
transient receptor potential cation channel subfamily M member 7 |
Tenuous |
|
TUBA4A |
tubulin alpha 4a |
Strong evidence |
|
UBQLN1 |
ubiquilin 1 |
Tenuous |
|
UBQLN2 |
ubiquilin 2 |
Definitive ALS gene |
|
UNC13A |
unc-13 homolog A |
Definitive ALS gene |
|
VAPB |
VAMP associated protein B and C |
Definitive ALS gene |
|
VCP |
valosin containing protein |
Definitive ALS gene |
|
VDR |
vitamin D receptor |
Tenuous |
|
VEGFA |
vascular endothelial growth factor A |
Tenuous |
|
VPS54 |
VPS54 subunit of GARP complex |
Tenuous |
|
VRK1 |
VRK serine/threonine kinase 1 |
Tenuous |
|
ZFP64 |
ZFP64 zinc finger protein |
Tenuous |
|
ZNF512B |
zinc finger protein 512B |
Tenuous |
|
ZNF746 |
zinc finger protein 746 |
Tenuous |